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The diagnosis and treatment of acquired Myasthenia Gravis in two adult dogs using oral neostigmine bromide

Authors:

D.R.A. Dissanayake ,

Veterinary Teaching Hospital, Department of Veterinary Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, LK
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I.D. Silva,

Veterinary Teaching Hospital, Department of Veterinary Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, LK
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Y.U. de Silva Senapathi,

Veterinary Teaching Hospital, Department of Veterinary Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, LK
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D.D.N. de Silva,

Veterinary Teaching Hospital, Department of Veterinary Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, LK
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M.D.H.S. Mallikarachchi,

Veterinary Teaching Hospital, Department of Veterinary Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, LK
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W.G.D.A. Gunathilaka,

Veterinary Teaching Hospital, Department of Veterinary Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, LK
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W.R.B. Kumara,

Veterinary Teaching Hospital, Department of Veterinary Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, LK
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E. Rajapaksha,

Veterinary Teaching Hospital, Department of Veterinary Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, LK
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W.C.R. Fernando

Veterinary Teaching Hospital, Department of Veterinary Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, LK
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Abstract

Two adult dogs aged 3.5 and 9 years were diagnosed with acquired Myasthenia Gravis (MG) based on clinical signs and positive response to oral neostigmine bromide (0.25mg/Kg BW) within 4 hours of oral administration. Both patients were successfully treated using neostigmine (1mg/Kg BW daily) alone or with neostigmine (1mg/Kg BW daily) and prednisolone (1mg/Kg BW, q12h) combination. Serum alkaline phosphatase and albumin/ globulin ratio monitored in one of the above patients starting from one month prior to development of generalized clinical signs until complete recovery, showed significant alterations which can be used in diagnosing MG and in monitoring the response to treatment.

How to Cite: Dissanayake, D.R.A. et al., (2016). The diagnosis and treatment of acquired Myasthenia Gravis in two adult dogs using oral neostigmine bromide. Sri Lanka Veterinary Journal. 63(1), pp.27–31. DOI: http://doi.org/10.4038/slvj.v63i1.5
Published on 30 Jun 2016.
Peer Reviewed

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